Example sentences of "[conj] it is [adv] known [adv] " in BNC.

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1 Although it is well known nowadays that , in addition to the noxious cereal grains , genetic factors may predispose susceptible subjects to an immune response that damages the small intestinal mucosa and the other environmental factors may triggerthis abnormal immune response , it was Dicke 's astute observations some 50 years ago that first changed the prognosis and treatment of these patients dramatically .
2 The Royal Navy says it will be a routine departure for them , although it is not known yet how Cammell Laird will mark the event .
3 They also plan to contact local doctors and hospitals in case the man sought medical treatment for the bites , although it is not known how serious his injuries were .
4 It has no cellars in which material could have been stored for safety , and it is not known how much had been removed elsewhere .
5 Others were selected , and it is not known how , as the parish church for an area , in which the sacraments of baptism , marriage and burial were allowed .
6 At the time of the investigation , 300 cases were still in hospital and it is not known how many will later develop cirrhosis of the liver , to which veno-occlusive disease is known to be contributory factor .
7 Nevertheless the Act is based upon this distinction ; some other countries have followed the logic and applied the legislation to all forms of information systems , whether manual or electronic , but it is not known how effective such legislation is .
8 But it is not known how these skills relate to levels of proficiency or to the process of acquisition .
9 Though it is not known how the two friends met , they were corresponding with each other by 1945 , Vaughan sharing with Minton , in the immediate aftermath of war , his mood of cynical disaffection .
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