Example sentences of "[noun] activate [noun sg] be " in BNC.
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| 1 | Plasminogen activating activity was significantly lower in malignant ascites ( n=10 , median <0.02 ( range <0.02–1.26 ) IU/ml ) than in alcoholic ascites ( n=10 , 1.07 ( 0.30–1.49 ) IU/ml ) ( p<0.05 ) . |
| 2 | Plasminogen activating activity was determined by the fibrin plate method after incubation for 24 hours at 37°C and the results expressed as IU tissue polasminogen activator/ ml ascitic fluid ( lower limit of detection 0.02 IU/ ml ) . |
| 3 | The plasminogen activating activity was significating higher in alcoholic cirrhotic ascites ( median 1.07 ( range 0.30–1.49 ) IU/ml ) than in malignant ascites ( <0.02 ( <0.02–1.26 ) IU/ml , p<0.05 ) . |
| 4 | Platelet activating factor is on of lipid mediators that is generated in a variety of cells upon chemical or immune stimulation . |
| 5 | Taken together with the present results , platelet activating factor is likely to modulate regional fibrinolytic activity during gastric mucosal injury induced by endothelin-1 . |
| 6 | Platelet activating factor is a low molecular weight phospholipid exhibiting potent biological effects including the platelet and neutrophil aggregation , systemic hypotension , pulmonary hypertension , and capillary leakage leading to haemorrhagic damage in the gastrointestinal tract . |
| 7 | Such excessive contents of platelet activating factor could result in further stimulation of acinar cells as platelet activating factor is capable of inducing the secretion of enzymes , of reducing the blood flow , and increasing vascular permeability leading to tissue oedema and injury . |
| 8 | These results support the concept that platelet activating factor is capable of inducing pancreatitis similar to that observed after infusion of caerulein and that it is mediated by specific platelet activating factor receptors . |
| 9 | Although platelet activating factor is capable of stimulating enzyme secretion from the isolated acinar cells , according to our results , it actually inhibits this secretion in vivo and this inhibition can be reversed by the pretreatment with TCV-309 . |
| 10 | Platelet activating factor is a lipid mediator derived from membrane phospholipids and involving in hypersensitivity and inflammatory reactions . |
| 11 | In conclusion , the colonic platelet activating factor is raised in acute Crohn 's disease patients irrespective of the severity or the type of inflammatory cell infiltration . |
| 12 | Platelet activating factor is synthetised by numerous human cell types , including neutrophils , minocytes , macrophages , platelets , eosiniophils , vascular endothelial cells , and several cancer cell lines . |
| 13 | Two metabolic steps play a part in platelet activating factor biosynthesis : firstly , phospholipase A 2 acts on membrane choline containing alkyl phospholipids such as alkyl-acyl-glycerophosphocholine ( AAGPC ) resulting in the production of lyso platelet activating factor , that is — 1-O-alkyl-sn-glycero-3-phosphocholine ; secondly , this lyso platelet activating factor is acetylated by an acetyltransferase to yield the biologically active molecule . |
| 14 | Platelet activating factor is one of the most potent lipid mediators discovered , which exerts a wide span of cellular and tissular effects ranging from degranulation of inflammatory cells to mucosal ulceration and necrosis . |
| 15 | Biological activity of platelet activating factor was measured by platelet aggregation using a Chrono-log Corporation aggregometer . |
| 16 | Pancreatic blood flow as measured by laser Doppler flowmetry at the end of a five hour infusion of caerulein or five hours after injection of platelet activating factor was reduced by about 50% ( Fig 5 ) . |
| 17 | In rats pretreated with TCV-309 plus caerulein , the content of pancreatic platelet activating factor was significantly ( p<0.05 ) smaller ( 4.5 ( 1.6 ) pg/ 100 mg ) than in those treated with caerulein alone but about three times higher than in saline treated rats . |
| 18 | As the administration of platelet activating factor was reported to increase the release of leukotriene C 4 that is known to cause a potent vasoconstriction , it is likely that both platelet activating factor and LTC 4 play a synergistic role in the pathogenesis of acute pancreatitis . |
| 19 | Extraction of platelet activating factor was performed during 10 hours at -4°C using a ‘ roller ’ . |
| 20 | Lyso platelet activating factor was chemically acetylated into platelet activating factor , extracted in ethanol and measured as previously described . |
| 21 | The amount of lyso platelet activating factor was calculated as the difference between the quantity of platelet activating factor measured after and before acetylation of the samples . |
| 22 | The dried residues were then acetylated as described above and platelet activating factor was assayed . |
| 23 | The mucosal content of platelet activating factor was higher ( p<0.01 ) in inflamed than in non-inflamed mucosa , but no significant correlation was observed with the severity of mucosal inflammation ( Fig 3 ) . |
| 24 | Platelet activating factor was extracted from biopsies using ethanolic extraction as previously reported by us and others . |
| 25 | In addition platelet activating factor was also found , although to a lesser extent in normal , uninflamed mucosa . |
| 26 | platelet activating factor was detected at low concentration in 4/13 subjects under basal condition ( mean ( SEM ) 1.2 ( 0.6 ) pg/hr ) while high concentrations of lyso platelet activating factor ( 6.1 ( 1.8 ) µg/hr ) and of alkyl-acyl-glycerophosphocholine ( AAGPC ) ( 11.5 ( 3 ) µg/hr ) were found in 13 and 11 subjects , respectively . |
| 27 | Platelet activating factor was not detected during pentagastrin infusion , while lyso platelet activating factor and alkyl-acyl-glycerophosphocholine were detected in 13 and in 12 subjects , respectively . |
| 28 | Platelet activating factor concentration was measured in each 15 minute sample , then lyso platelet activating factor was assessed after chemical acetylation and AAGPC after alkaline hydrolysis and subsequent acetylation . |
| 29 | Assay for lyso platelet activating factor — Lyso platelet activating factor was measured after chemical acetylation into platelet activating factor . |
| 30 | The amount of lyso platelet activating factor was calculated as the difference between the quantity of platelet activating factor measured after and before acetylation of the samples . |